There have been no signs of any toxins in Cissus across many clinical studies. In fact, Cissus Quadrangularis (Adamant Creeper) is an anti-oxidant. There are no dangers with Cissus and no overdoses. However, if you are pregnant or taking meds you should consult your physician before taking any herbal supplements
The best time to take cissus is 20-30 minutes before meals. This time allows your body to absorb all the vitamins and nutrients before it starts trying to digest food. First thing in the morning is the absolute best time to take cissus, since this is when our cortisol levels are highest and our bodies are ready to absorb all the goodness.
Cissus is grown throughout tropical Asia and parts of Africa. It is most widely grown in India, but also in Southeast Asia such as in Thailand.
The use of cissus quadrangularis dates back to ayurvedic times thousands of years ago in India. Since then there have been many clinical studies done with Cissus.